Publications

Cote AL, McIntyre CL, Acklin JA, Delacruz LR, Qiu Y, Kurland IJ, Ringel AE. Citrate Compartmentalization Controls Calcium-Dependent Cytokine Production in Effector T Cells. (2026) bioRxiv. doi: 10.64898/2026.06.11.731694.

Delacruz LR, Ye M, Libby KA, Han K, Munger CJ, Qiu Y, Kurland IJ, Ringel AE. A Live-Cell Method for Profiling Bioenergetic Heterogeneity by Noncanonical Methionine Labeling of the Cell Surface Proteome. (2026) bioRxiv. doi: 10.64898/2026.06.01.729353.

Padilla-Gomez J, McGinn R, De Andrade V, Liang Y, Libby KA, Ni H, Ringel AE, Evavold C, Bryson, BD. Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species. (2026) mSphere. In press.

Xu L, Bottermann M, Villavicencio PM, Warner J, Weldon SR, Xie Z, Filby A, Liu X, Ganley IG, Ringel AE, Nair U, Batista FD. FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. (2026) Journal of Experimental Medicine. 223(3): e20250535. PMID: 41405578.

Adhikari DA, Froehle LM, Pipkin AN, Baharlou H, Linder AH, Shah P, Hussey A, Zhang Q, Nyquist S, Khawaled S, Chi F, Goswami S, Sedhain S, Hussain S, Diefenbach TJ, Read BJ, Kim B, Irvine D, Asowata O, Ladinsky M, Bjorkman P, Madela F, Kader S, Shalek AK, Ghebremichael M, Kloverpris H, Ringel AE, Yilmaz OH, and Kwon DS. Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV. (2025) Cell. 188(20):5666-5679.e19. PMID: 40939591.

Dolan M, Libby KA, Ringel AE, van Galen P, McAllister SS. Ageing, immune fitness and cancer. (2025) Nat Rev Cancer. 25(11):848-872. PMID: 40813902. *One of top 10 most downloaded review articles in 2025 from Nature Reviews Cancer

Pauken KE, Markson SC, Conway TS, Juneja VR, Shahid O, Burke KP, Rowe JH, Nguyen TH, Collier JL, Walsh JML, Fung ME, Luber JM, Ringel AE, Schenkel JM, Freeman GJ, Haigis MC, Singer M, Sharpe AH. PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion. (2025) Journal of Experimental Medicine. 222(10): e20230542. PMID: 40705010.

Kelley LP, Hu S-H, Boswell SA, Sorger PK, Ringel AE, Haigis MC. Integrated analysis of transcriptional and metabolic responses to mitochondrial stress. (2025) Cell Rep Methods. 5(4):101027. PMID: 40233762. 

Cote AL, Munger CJ, Ringel AE. Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions. (2025) Cell Reports. 44(2):115234. PMID: 39862435.

Georgiev P**, Han S**, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao C-H, Park J-S, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH*, Haigis MC*, Ringel AE*. Age-associated contraction of tumor-specific T cells impairs antitumor immunity. (2024) Cancer Immunology Research. OF1–OF17. PMID: 39186561.

Han SJ, Georgiev P, Ringel AE, Sharpe AH, Haigis MC. Age-associated remodeling of T cell immunity and metabolism. (2023) Cell Metabolism 35(1):36-55. PMID: 36473467.

Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin J-R, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suva ML, Haigis MC. Oncometabolite D-2HG alters T cell metabolism to impair CD8+ T cell function. (2022) Science 377(6614):1519-1529. PMID 36173860.

Wong SJ, Ringel AE, Yuan W, Yoon H, Currie MA, Paulo JA, Haigis MC.  Development of a colorimetric a-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins. (2021) JBC 296:100397. PMID 33571527.

Drijvers J, Gillis J, Muijlwijk T, Nguyen T, Gaudiano E, Harris I, LaFleur M, Ringel AE, Yao C-H, Kurmi K, Juneja V, Trombley J, Haigis MC, and Sharpe A. Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T cells. (2021) Cancer Immunology Research 9(2): 184-199. PMID 33277233.

`Ringel AE*,Drijvers JD*, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway B, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao C-H, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, and Haigis MC. Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. (2020) Cell 183(17):1848-1866. PMID 33301708.

Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, and Sorger PK. Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. (2019) Cell Systems 8(5):412-26. PMID 31078528.

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, and Kaelin WG Jr. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. (2019) Science 363(6432):1217-22. PMID 30872525.

Ringel AE, Tucker SA, and Haigis MC. Chemical and Physiological Features of Mitochondrial Acylation. (2018) Molecular Cell 72(4):610-24. PMID 30444998.

Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, and Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. (2017) Science 358(6365):941-6. PMID 29025995.

Ondracek CR, Frappier V, Ringel AE, Wolberger C, and Guarente L. Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. (2017) Cell Reports 18(10):2310-9. PMID 28273448.

Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, and Haigis MC. Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell (2016) 167(4):985-1000. PMID 27881304.

Ringel AE and Wolberger C. Structures of the catalytic domain of human Gcn5L2 bound to propionyl- and butyryl-CoA. (2016) Acta Crystallographica D. (72): 841-8. PMID 27377381.

Morgan MT, Haj-Yahya M, Ringel AE, Bandi P, Brik A, and Wolberger C. Structural basis for H2B deubiquitination by the SAGA DUB module. (2016) Science 351(6274):725-8. PMID 26912860.

Ringel AE, Cieniewicz AM, Taverna SD, and Wolberger C. Nucleosome competition reveals processive acetylation by the SAGA HAT module. (2015) PNAS. 112:E5461-5470. PMID 26401015.

Ringel AE, Roman C, and Wolberger C. Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. (2014) Protein Science. 23:1686-97. PMID 25200501.

Cieniewicz AM, Moreland L, Ringel AE, Mackintosh SG, Raman A, Gilbert TM, Wolberger C, Tackett AJ, and Taverna SD. The bromodomain of Gcn5 regulates site-specificity of lysine acetylation on histone H3. (2014) Mol Cell Proteomics. 13:2896-910. PMID 25106422.

Guzzo CM, Ringel A, Cox E, Uzoma I, Zhu H, Blackshaw S, Wolberger C, and Matunis MJ. Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers ZNF261 and ZNF198. (2014) PLoS One. 8:e105271. PMID 25133527.

Ringel AE and Wolberger C. A new RING tossed into an old HAT. (2013) Structure. 21:1479-81. PMID 24010705.

Berndsen CE, Wiener R, Yu IW, Ringel AE, and Wolberger C. A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. (2013) Nat Chem Biol.9:154-6. PMID 23292652.

Ringel AE*, Ryznar R*, Picariello H, Huan KL, Lazarus AG, and Holmes SG. Tdh3 (glyceraldehyde-3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. (2013) Yeast PLoS Genetics. 9:e1003871. PMID 24146631.

Samara NL, Ringel AE, and Wolberger C. A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity. (2012) Structure. 20: 1414-24. PMID 22771212.